Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.

Genes & development - 15 Sept 2015

Boynton Tye O'Hara, Shimkets Lawrence Joseph

Abstract excerpt

Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins. We show that CsgA and SocA, a protein that can replace CsgA function in vivo, oxidize the 2'-OH glycerol moiety on cardiolipin and phosphatidylglycerol to produce diacylglycerol (DAG), dihydroxyacetone, and orthophosphate. A lipid extract enriched in DAGs from wild-type cells initiates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3-Hydroxyacyl CoA Dehydrogenases
Share to Alcohol Oxidoreductases
Share to Cardiolipins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diglycerides

Share to Lipid Droplets

Share to Phosphates

Share to Phosphatidylglycerols

Share to Transferases (Other Substituted Phosphate Groups)

Source

Open in PubMed Open full text

Identifiers

PMID: 26338420
DOI: 10.1101/gad.268482.115
PMCID: PMC4579348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases.PMID 26338420Read ↗

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathwaysSemantic proximity Read ↗

Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.Semantic proximity Read ↗

X-linked cardioskeletal myopathy and neutropenia (Barth syndrome): an update.Semantic proximity Read ↗

Characterization of a Novel Splicing Variant in Acylglycerol Kinase (AGK) Associated with Fatal Sengers Syndrome.Semantic proximity Read ↗

Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast.Semantic proximity Read ↗

The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.Semantic proximity Read ↗

A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.Semantic proximity Read ↗

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target.Semantic proximity Read ↗

Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.Semantic proximity Read ↗

Myeloid Suclg2 deficiency attenuates aortic dissection by reshaping succinate-associated macrophage remodellingSemantic proximity Read ↗

Short-chain acyl-CoA dehydrogenase deficiency: from gene to cell pathology and possible disease mechanisms.Semantic proximity Read ↗

Fatty acid synthase cooperates with glyoxalase 1 to protect against sugar toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.