Article
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway.
Molecular cell - 25 May 2012
Nakahara Kanae, Ohkuni Aya, Kitamura Takuya, Abe Kensuke, Naganuma Tatsuro, Ohno Yusuke, Zoeller Raphael A, Kihara Akio
Abstract excerpt
Sphingosine 1-phosphate (S1P) functions not only as a bioactive lipid molecule, but also as an important intermediate of the sole sphingolipid-to-glycerolipid metabolic pathway. However, the precise reactions and the enzymes involved in this pathway remain unresolved. We report here that yeast HFD1 and the Sjögren-Larsson syndrome (SLS)-causative mammalian gene ALDH3A2 are responsible for conversion of the S1P...
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