Article
Identification of a cardiolipin-specific phospholipase encoded by the gene CLD1 (YGR110W) in yeast.
The Journal of biological chemistry - 24 Apr 2009
Beranek Andreas, Rechberger Gerald, Knauer Heide, Wolinski Heimo, Kohlwein Sepp D, Leber Regina
Abstract excerpt
The mitochondrial dimeric phospholipid cardiolipin is characterized by a high degree of unsaturation of its acyl chains, which is important for its functional interaction with mitochondrial enzymes. The unusual fatty acid composition of cardiolipin molecular species emerges from a de novo synthesized "premature" species by extensive acyl chain remodeling that involves as yet only partially identified...
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