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Tumor-associated autoantibodies from mouse breast cancer models are found in serum of breast cancer patients

11 May 2021

Abstract excerpt

B cell responses to tumor antigens occur early in breast tumors and may identify immunogenic drivers of tumorigenesis. Sixty-two candidate antigens were identified prior to palpable tumor development in TgMMTV-neu and C3(1)Tag transgenic mouse mammary tumor models. Five antigens (VPS35, ARPC2, SERBP1, KRT8, and PDIA6) were selected because their decreased expression decreased survival in human HER2 positive and...

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PMID: 33976232
DOI: 10.1038/s41523-021-00257-1

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