Article
Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens.
Genomics - 15 Oct 1997
Fletcher C F, Okano H J, Gilbert D J, Yang Y, Yang C, Copeland N G, Jenkins N A, Darnell R B
Abstract excerpt
The paraneoplastic neurologic disorders (PND) are a rare group of neurologic syndromes that arise when an immune response to systemic tumors expressing neuronal proteins ("onconeural antigens") develops into an autoimmune neuronal degeneration. The use of patient antisera to clone the genes encoding PND antigens has led to new insight into the mechanism of these autoimmune disorders. The tumor antigens can now be...
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