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Article

MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants.

Plant physiology - 1 Jun 2011

Hakenjos Jana Pia, Richter René, Dohmann Esther Mirjam Natascha, Katsiarimpa Anthi, Isono Erika, Schwechheimer Claus

Abstract excerpt

The conjugation of the ubiquitin-like modifier NEURAL PRECURSOR CELL-EXPRESSED DEVELOPMENTALLY DOWN-REGULATED PROTEIN8/RELATED TO UBIQUITIN1 (NEDD8/RUB1; neddylation) is best known as an important posttranslational modification of the cullin subunits of cullin-RING-type E3 ubiquitin ligases (CRLs). MLN4924 has recently been described as an inhibitor of NEDD8-ACTIVATING ENZYME1 (NAE1) in human. Here, we show that...

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Source

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Identifiers

PMID: 21527421
DOI: 10.1104/pp.111.176677
PMCID: PMC3177256

Genes

NEDD8
NAE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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