Article
The development of rapid and accurate screening test for RET hotspot somatic and germline mutations in MEN2 syndromes.
Experimental and molecular pathology - 1 Dec 2015
Zupan Andrej, Glavač Damjan
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a rare endocrine malignancy with distinctive features separating it from other thyroid cancers. Cancer may be sporadic or occur as a consequence of the hereditary syndrome called multiple endocrine neoplasia type 2 (MEN2) with three distinct phenotypes in MEN2A, MEN2B and FMTC. Each variant of MEN2 results from different RET gene mutations, with a good genotype-phenotype...
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