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Article

Genetics of medullary thyroid cancer: An overview.

International journal of surgery (London, England) - 1 May 2017

Accardo Giacomo, Conzo Giovanni, Esposito Daniela, Gambardella Claudio, Mazzella Marco, Castaldo Filomena, Di Donna Carlo, Polistena Andrea, Avenia Nicola, Colantuoni Vittorio, Giugliano Dario, Pasquali Daniela

Abstract excerpt

Medullary thyroid carcinoma (MTC) represents 3-5% of thyroid cancers. 75% is sporadic and 25% is the dominant component of the hereditary multiple endocrine neoplasia (MEN) type 2 syndromes. Three different subtypes of MEN2, such as MEN2A, MEN2B, and Familial MTC (FMTC) have been defined, based on presence or absence of hyperparathyroidism, pheocromocytoma and characteristic clinical features. Mutations of the...

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PMID: 28506408
DOI: 10.1016/j.ijsu.2017.02.064

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