Article
De novo mutation of the RET proto-oncogene revealing multiple endocrine neoplasia type 2A: a sporadic case from Western Algeria.
The Gulf journal of oncology - 1 Sept 2025
Chami Amina, Romanet Pauline, Mohammedi Fatima, Benabadji Nadia, Habour Narimane, Derkaoui Dalia, Sahraoui Tewfik
Abstract excerpt
BACKGROUND: Multiple endocrine neoplasia type 2A (MEN2A) is a rare autosomal dominant disorder associated with RET proto-oncogene mutations. Early diagnosis is absolutely critical for managing and preventing aggressive forms of medullary thyroid carcinoma (MTC) and associated tumours. Our aims are to confirm the clinical diagnosis and to detect, in relatives, those who bear the familial mutation in order to...
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