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Article

Imbalances in p97 co-factor interactions in human proteinopathy.

EMBO reports - 1 Jun 2010

Fernández-Sáiz Vanesa, Buchberger Alexander

Abstract excerpt

The ubiquitin-selective chaperone p97 is involved in major proteolytic pathways of eukaryotic cells and has been implicated in several human proteinopathies. Moreover, mutations in p97 cause the disorder inclusion body myopathy with Paget disease of bone and frontotemporal dementia (IBMPFD). The molecular basis underlying impaired degradation and pathological aggregation of ubiquitinated proteins in IBMPFD is...

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Identifiers

PMID: 20414249
DOI: 10.1038/embor.2010.49
PMCID: PMC2892324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Imbalances in p97 co-factor interactions in human proteinopathy.PMID 20414249Read ↗

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