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Article

Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2004

Kozlenkov Alexey, Le Du Marie Helene, Cuniasse Philippe, Ny Tor, Hoylaerts Marc F, Millán José Luis

Abstract excerpt

UNLABELLED: Recent data have pointed to TNALP as a therapeutic target for soft-tissue ossification abnormalities. Here, we used mutagenesis, kinetic analysis, and computer modeling to identify the residues important for the binding of known ALP inhibitors to the TNALP active site. These data will enable drug design efforts aimed at developing improved specific TNALP inhibitors for therapeutic use. INTRODUCTION:...

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Source

Identifiers

PMID: 15476587
DOI: 10.1359/JBMR.040608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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