Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge.

doi:10.1097/JTO.0000000000000658

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Article

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2015

Pelosi Giuseppe, Fabbri Alessandra, Papotti Mauro, Rossi Giulio, Cavazza Alberto, Righi Luisella, Tamborini Elena, Perrone Federica, Settanni Giulio, Busico Adele, Testi Maria Adele, Maisonneuve Patrick, De Braud Filippo, Garassino Marina, Valeri Barbara, Sonzogni Angelica, Pastorino Ugo

Abstract excerpt

INTRODUCTION: Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung. METHODS: Thirty LCC were dissected by unsupervised targeted next generation sequencing analysis for 50 cancer-associated oncogenes and tumor suppressor genes. Cell differentiation lineages were unveiled by using thyroid transcription factor-1 (TTF1) for adenocarcinoma (ADC) and p40...

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Identifiers

PMID: 26317919
DOI: 10.1097/JTO.0000000000000658

Genes

TTF1
ATM
BRAF
EGFR
ERBB4
FLT3
KRAS
NRAS
PTPN11
RET
SMAD4
SMO
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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