Article
Genomic and pathological heterogeneity in clinically diagnosed small cell lung cancer in never/light smokers identifies therapeutically targetable alterations.
Molecular oncology - 1 Jan 2021
Ogino Atsuko, Choi Jihyun, Lin Mika, Wilkens Margaret K, Calles Antonio, Xu Man, Adeni Anika E, Chambers Emily S, Capelletti Marzia, Butaney Mohit, Gray Nathanael S, Gokhale Prafulla C, Palakurthi Sangeetha, Kirschmeier Paul, Oxnard Geoffrey R, Sholl Lynette M, Jänne Pasi A
Abstract excerpt
Small-cell lung cancer (SCLC) occurs infrequently in never/former light smokers. We sought to study this rare clinical subset through next-generation sequencing (NGS) and by characterizing a representative patient-derived model. We performed targeted NGS, as well as comprehensive pathological evaluation, in 11 never/former light smokers with clinically diagnosed SCLC. We established a patient-derived model from...
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