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Article

EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype.

The European respiratory journal - 1 Mar 2014

Warth Arne, Penzel Roland, Lindenmaier Heike, Brandt Regine, Stenzinger Albrecht, Herpel Esther, Goeppert Benjamin, Thomas Michael, Herth Felix J F, Dienemann Hendrik, Schnabel Philipp A, Schirmacher Peter, Hoffmann Hans, Muley Thomas, Weichert Wilko

Abstract excerpt

Numerous studies have been published on single aspects of pulmonary adenocarcinoma (ADC). To comprehensively link clinically relevant ADC characteristics, we evaluated established morphological, diagnostic and predictive biomarkers in 425 resected ADCs. Morphology was reclassified. Cytokeratin-7, thyroid transcription factor (TTF)1, napsin A, thymidylate synthase and excision repair cross-complementing rodent...

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Source

Identifiers

PMID: 23988776
DOI: 10.1183/09031936.00018013

Genes

BRAF
EGFR
KRAS
ALK
TTF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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