Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2013

Rekhtman Natasha, Tafe Laura J, Chaft Jamie E, Wang Lu, Arcila Maria E, Colanta Agnes, Moreira Andre L, Zakowski Maureen F, Travis William D, Sima Camelia S, Kris Mark G, Ladanyi Marc

Abstract excerpt

Pulmonary large-cell carcinoma-a diagnostically and clinically controversial entity-is defined as a non-small-cell carcinoma lacking morphologic differentiation of either adenocarcinoma or squamous cell carcinoma, but suspected to represent an end stage of poor differentiation of these tumor types. Given the recent advances in immunohistochemistry to distinguish adenocarcinoma and squamous cell carcinoma, and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Carcinoma, Large Cell

Share to Carcinoma, Squamous Cell

Share to Immunohistochemistry

Share to In Situ Hybridization, Fluorescence

Share to Kaplan-Meier Estimate

Share to Lung Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 23196793
DOI: 10.1038/modpathol.2012.195
PMCID: PMC3594043

Genes

ALK
BRAF
EGFR
KRAS
AKT1
ERBB2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct profile of driver mutations and clinical features in immunomarker-defined subsets of pulmonary large-cell carcinoma.PMID 23196793Read ↗

Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas Reclassified by World Health Organization 2015 Criteria.Semantic proximity Read ↗

Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge.Semantic proximity Read ↗

Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations.Semantic proximity Read ↗

EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype.Semantic proximity Read ↗

Molecular dissection of large cell carcinomas of the lung with null immunophenotype.Semantic proximity Read ↗

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer.Semantic proximity Read ↗

Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology.Semantic proximity Read ↗

What's new in non-small cell lung cancer for pathologists: the importance of accurate subtyping, EGFR mutations and ALK rearrangements.Semantic proximity Read ↗

Molecular pathology of non-small cell lung cancer: a practical guide.Semantic proximity Read ↗

Correlation of Histologic Subtypes and Molecular Alterations in Pulmonary Adenocarcinoma: Therapeutic and Prognostic Implications.Semantic proximity Read ↗

Simplified Molecular Classification of Lung Adenocarcinomas Based on EGFR, KRAS, and TP53 MutationsSemantic proximity Read ↗

Lung Carcinoma Predictive Biomarker Testing by Immunoperoxidase Stains in Cytology and Small Biopsy Specimens: Advantages and Limitations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.