Article
A variant in 3'-untranslated region of KRAS compromises its interaction with hsa-let-7g and contributes to the development of lung cancer in patients with COPD.
International journal of chronic obstructive pulmonary disease - 1 Jan 2015
Hu Hua, Zhang Linlin, Teng Geling, Wu Yanhua, Chen Ying
Abstract excerpt
OBJECTIVE: The objective of the present study was to explore the molecular mechanism by which a single nucleotide polymorphism (rs712) interferes with interaction between 3'-untranslated region (3'-UTR) of KRAS and let-7g, and its association with development of lung cancer in the patients with COPD. MATERIALS AND METHODS: In this study, we confirmed that KRAS is a target of let-7g in lung cancer cells, and that...
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