A single nucleotide polymorphism in the 3'-untranslated region of the KRAS gene disrupts the interaction with let-7a and enhances the metastatic potential of osteosarcoma cells.

doi:10.3892/ijmm.2016.2661

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Article

A single nucleotide polymorphism in the 3'-untranslated region of the KRAS gene disrupts the interaction with let-7a and enhances the metastatic potential of osteosarcoma cells.

International journal of molecular medicine - 1 Sept 2016

Zhang Shiqian, Hou Chunying, Li Guojun, Zhong Yang, Zhang Jie, Guo Xinzhen, Li Baoxin, Bi Zhenggang, Shao Ming

Abstract excerpt

The objective of the present study was to explore the molecular mechanism with which a single nucleotide polymorphism (rs61764370) interferes with the interaction between the 3'-untranslated region (3'-UTR) of Kirsten rat sarcoma viral oncogene homolog (KRAS) and let-7a, and its association with the metastasis of osteosarcoma (OS). In this study, we confirmed that KRAS is a target of let-7a in OS cells, and the...

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PMID: 27430246
DOI: 10.3892/ijmm.2016.2661

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KRAS

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A single nucleotide polymorphism in the 3'-untranslated region of the KRAS gene disrupts the interaction with let-7a and enhances the metastatic potential of osteosarcoma cells.PMID 27430246Read ↗

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