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Article

c-di-GMP inhibits LonA-dependent proteolysis of TfoY in Vibrio cholerae.

PLoS genetics - 1 Jun 2020

Joshi Avatar, Mahmoud Samar A, Kim Soo-Kyoung, Ogdahl Justyne L, Lee Vincent T, Chien Peter, Yildiz Fitnat H

Abstract excerpt

The LonA (or Lon) protease is a central post-translational regulator in diverse bacterial species. In Vibrio cholerae, LonA regulates a broad range of behaviors including cell division, biofilm formation, flagellar motility, c-di-GMP levels, the type VI secretion system (T6SS), virulence gene expression, and host colonization. Despite LonA's role in cellular processes critical for V. cholerae's aquatic and...

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Identifiers

PMID: 32589664
DOI: 10.1371/journal.pgen.1008897
PMCID: PMC7371385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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