Proteolytically Coordinated Activation of Toxin-Antitoxin Modules

Abstract excerpt

Chronic bacterial infections present a serious threat to the health of humans by decreasing life expectancy and quality. Resilience of these populations is closely linked to a small fraction of persister cells that are capable of surviving a wide range of environmental stressors that include starvation, DNA damage, heat shock, and antibiotics. In contrast to inherited resistance, persistence arises from a rare and...

Topics

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• Anti-Bacterial Agents
• Bacterial Toxins
• Drug Discovery
• Drug Resistance, Bacterial
• Escherichia coli
• Models, Biological
• Mutation
• Phenotype

Identifiers and source

Literature Corpus work

e45dc77f-d5c5-5119-87ea-979d31894db5

DOI

10.1101/146027