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Article

Effects of CYP2C19 Polymorphism on Endothelial Function, Arterial Stiffness and Inflammation in Coronary Artery Disease Patients Under Clopidogrel Treatment.

Current pharmaceutical design - 1 Jan 2015

Siasos Gerasimos, Zaromitidou Marina, Oikonomou Evangelos, Mourouzis Konstantinos, Tsalamandris Sotiris, Kioufis Stamatios, Kokkou Eleni, Vavuranakis Manolis, Zografos Theodoros, Antonopoulos Alexis, Dimitropoulos Stathis, Stefanadis Christodoulos, Papavassiliou Athanasios G, Tousoulis Dimitris

Abstract excerpt

BACKGROUND: Clopidogrel's ability to inhibit platelet function determined its clinical usefulness. The role of CYP2C19*2 genotype on antiplatelet treatment is recently under question. Arterial wall properties and inflammation are key players in atherosclerosis development. Hence, we evaluated the impact of CYP2C19*2 genetic polymorphism on endothelial function, arterial stiffness and inflammation in coronary...

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Identifiers

PMID: 26311225
DOI: 10.2174/1381612821666150827124459

Genes

CAD
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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