Article
Non-antiplatelet effect of clopidogrel: improving endothelial function in Chinese healthy subjects with different CYP2C19 genotype.
Clinical and experimental pharmacology & physiology - 1 Jan 2015
Zhang Yin-Zhuang, Chen Bi-Lian, Zhang Wei, Cao Xin
Abstract excerpt
Clopidogrel has been shown to improve endothelial function in vitro and in patients with coronary artery disease. However, it remains unclear whether such an effect of clopidogrel is associated with CYP2C19 polymorphisms that determine the antiplatelet effect of clopidogrel. After genotyping, 12 healthy participants were enrolled in the study. Among them, six participants were CYP2C19*1/*1 (extensive...
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