Article
Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 9 Jan 2017
Marchini J F M, Pinto M R, Novaes G C, Badran A V, Pavão R B, Figueiredo G L, Lago I M, Lima-Filho M O, Lemos D C, Tonani M, Antloga C M, Oliveira L, Lorenzi J C, Marin-Neto J A
Abstract excerpt
Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern. Populations with higher degrees of genetic admixture may have increased prevalence of clopidogrel hyporesponsiveness. To assess this, we genotyped CYP2C19, ABCB1, and PON1 in 187 patients...
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