Article
Patients with both CYP2C19 loss-of-function allele and peripheral endothelial dysfunction are significantly correlated with adverse cardiovascular events following coronary stent implantation.
Journal of cardiology - 1 Jan 2016
Tabata Noriaki, Hokimoto Seiji, Akasaka Tomonori, Arima Yuichiro, Sakamoto Kenji, Yamamoto Eiichiro, Tsujita Kenichi, Izumiya Yasuhiro, Yamamuro Megumi, Kojima Sunao, Kaikita Koichi, Kumagae Naoki, Morita Kazunori, Oniki Kentaro, Nakagawa Kazuko, Matsui Kunihiko, Ogawa Hisao
Abstract excerpt
BACKGROUND: There is some controversy regarding the effect of CYP2C19 polymorphism on clinical outcome in patients receiving dual antiplatelet therapy (DAPT). Peripheral endothelial dysfunction has recently been reported to predict adverse cardiovascular events. We hypothesized that CYP2C19 loss-of-function (LOF) allele carriers with peripheral endothelial dysfunction had worse prognosis. The aim of this study...
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