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Article

The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.

Molecular cancer therapeutics - 1 May 2014

Moen Erika L, Stark Amy L, Zhang Wei, Dolan M Eileen, Godley Lucy A

Abstract excerpt

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is known to play a role in sensitivity to temozolomide. Promoter hypermethylation of MGMT is commonly used to predict low expression levels of MGMT in gliomas, despite observed discordance between promoter methylation and protein levels. Here, we investigated the functional role of gene body cytosine modification in regulating levels of MGMT...

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Source

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Identifiers

PMID: 24568970
DOI: 10.1158/1535-7163.MCT-13-0924
PMCID: PMC4013207

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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