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Article

Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions

26 Feb 2020

Abstract excerpt

Temozolomide (TMZ) is a drug of choice in glioblastoma treatment. Its therapeutic applications expand also beyond high grade gliomas. However, a significant number of recurrences and resistance to the drug is observed. The key factor in each chemotherapy is to achieve the therapeutic doses of a drug at the pathologic site. Nonetheless, the rate of temozolomide penetration from blood to cerebrospinal fluid is only...

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PMID: 32101575
DOI: 10.1371/journal.pone.0229534

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