Article

Sensitivity to temozolomide of cell lines derived from brain tumours and melanomas: relationship to MGMT gene expression

2024-12-05

Abstract excerpt

<h4>Background</h4> We have developed a series of low-passage melanoma and glioma cell lines and are using them to study responses to antitumour drugs. Here we have assessed responses to temozolomide, a commonly used clinical drug used for the treatment of glioblastoma and melanoma. Temozolomide acts mainly by methylation of DNA guanine and lesions can be removed by the repair enzyme O 6 -methylguanine-DNA methy...

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Literature Corpus work: 2701770b-b2b5-5a81-bd28-f80ced4b73d5
DOI: 10.1101/2024.11.30.626133

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