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Article

Overexpression of Both ERG11 and ABC2 Genes Might Be Responsible for Itraconazole Resistance in Clinical Isolates of Candida krusei

26 Aug 2015

Abstract excerpt

OBJECTIVE: To study the main molecular mechanisms responsible for itraconazole resistance in clinical isolates of Candida krusei. METHODS: The 14α-demethylases encoded by ERG11 gene in the 16 C.krusei clinical isolates were amplified by polymerase chain reaction (PCR), and their nucleotide sequences were determined to detect point mutations. Meanwhile, ERG11 and efflux transporters (ABC1 and ABC2) genes were...

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PMID: 26308936
DOI: 10.1371/journal.pone.0136185

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