Article
Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.
Antimicrobial agents and chemotherapy - 1 Feb 2009
Lamping Erwin, Ranchod Amrita, Nakamura Kenjirou, Tyndall Joel D A, Niimi Kyoko, Holmes Ann R, Niimi Masakazu, Cannon Richard D
Abstract excerpt
Most Candida krusei strains are innately resistant to fluconazole (FLC) and can cause breakthrough candidemia in immunocompromised individuals receiving long-term prophylactic FLC treatment. Although the azole drug target, Erg11p, of C. krusei has a relatively low affinity for FLC, drug efflux pumps are also believed to be involved in its innate FLC resistance. We describe here the isolation and characterization...
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