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Identification and Characterization of Androgen-Responsive Genes in Zebrafish Embryos

26 Aug 2015

Abstract excerpt

Responsive genes for fish embryos have been identified so far for some endocrine pathways but not for androgens. Using transcriptome analysis and multiple concentration-response modeling, we identified putative androgen-responsive genes in zebrafish embryos exposed to 0.05-5000 nM 11-ketotestosterone for 24 h. Four selected genes with sigmoidal concentration-dependent expression profiles (EC50 = 6.5-30.0 nM) were...

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PMID: 26308493
DOI: 10.1021/acs.est.5b01034

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