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Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiation

10 Apr 2020

Abstract excerpt

Brain sex differentiation is a complex process, wherein genes and steroid hormones act to induce specific gender brain differentiation. Testosterone (T) derived from the gonads has been linked to neural circuit modeling in a sex-specific manner. Previously, we have shown that cyp17a1 knockout (KO) zebrafish have low plasma androgen levels, and display compromised male-typical mating behaviors. In this study, we...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hormonal and reproductive studies
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PMID: 32283058
DOI: 10.1016/j.ygcen.2020.113490

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