Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simultaneous exposure to estrogen and androgen resulted in feminization and endocrine disruption.

The Journal of endocrinology - 1 Mar 2016

Chen Lili, Jiang Xiaolong, Feng Haiwei, Shi Hongjuan, Sun Lina, Tao Wenjing, Xi Qingping, Wang Deshou

Abstract excerpt

Estrogen, which is synthesized earlier in females than androgen in males, is critical for sex determination in non-mammalian vertebrates. However, it remains unknown that what would happen to the gonadal phenotype if estrogen and androgen were administrated simultaneously. In this study, XY and XX tilapia fry were treated with the same dose of 17α-methyltestosterone (MT) and 17β-estradiol (E2) alone and in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocrine Disruptors
Share to Estradiol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fish Diseases

Share to Gene Expression

Share to Phenotype

Share to Sex Factors

Share to Testosterone

Share to Tilapia

Source

Identifiers

PMID: 26759274
DOI: 10.1530/JOE-15-0432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simultaneous exposure to estrogen and androgen resulted in feminization and endocrine disruption.PMID 26759274Read ↗

Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Semantic proximity Read ↗

Cyp17a1 is Required for Female Sex Determination and Male Fertility by Regulating Sex Steroid Biosynthesis in FishSemantic proximity Read ↗

Mutation of foxl2 or cyp19a1a Results in Female to Male Sex Reversal in XX Nile Tilapia.Semantic proximity Read ↗

dmrt1 Is Responsible for Androgen-Induced Masculinization in Nile Tilapia.Semantic proximity Read ↗

The sensitive period for male-to-female sex reversal begins at the embryonic stage in the Nile tilapia and is associated with the sexual genotype.Semantic proximity Read ↗

The effects of 17α‐methyltestosterone on gonadal histology and gene expression along hypothalamic‐pituitary‐gonadal axis, germ cells, sex determination, and hypothalamus‐pituitary‐thyroid axis in zebrafish ( Danio rerio )Semantic proximity Read ↗

Mutation ofcyp19a1bresults in sterile males due to efferent duct obstruction in Nile tilapiaSemantic proximity Read ↗

Dietary aromatase inhibitor treatment converts XY gsdf homozygous mutants to sub-fertile male in Nile tilapia (Oreochromis niloticus)Semantic proximity Read ↗

Estrogen exposure overrides the masculinizing effect of elevated temperature by a downregulation of the key genes implicated in sexual differentiation in a fish with mixed genetic and environmental sex determinationSemantic proximity Read ↗

Gene expression profiles revealing the mechanisms of anti-androgen- and estrogen-induced feminization in fishSemantic proximity Read ↗

Zebrafish cyp17a1 knockout reveals that androgen-mediated signaling is important for male brain sex differentiationSemantic proximity Read ↗

Oxidative Stress Causes Masculinization of Genetically Female Medaka Without Elevating CortisolSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.