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Article

Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists.

Reproductive toxicology (Elmsford, N.Y.) - 1 Apr 2018

Haggard Derik E, Noyes Pamela D, Waters Katrina M, Tanguay Robert L

Abstract excerpt

There continues to be a need to develop in vivo high-throughput screening (HTS) and computational methods to screen chemicals for interaction with the estrogen, androgen, and thyroid pathways and as complements to in vitro HTS assays. This study explored the utility of an embryonic zebrafish HTS approach to identify and classify endocrine bioactivity using phenotypically-anchored transcriptome profiling....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Thyroid Hormone

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Source

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Identifiers

PMID: 29458080
DOI: 10.1016/j.reprotox.2018.02.006
PMCID: PMC5878140

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