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Article

A molecular and phenotypic integrative approach to identify a no-effect dose level for antiandrogen-induced testicular toxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2011

Ludwig Sophie, Tinwell Helen, Schorsch Frédéric, Cavaillé Christel, Pallardy Marc, Rouquié David, Bars Rémi

Abstract excerpt

The safety assessment of chemicals for humans relies on identifying no-observed adverse effect levels (NOAELs) in animal toxicity studies using standard methods. With the advent of high information content technologies, especially microarrays, it is pertinent to determine the impact of molecular data on the NOAELs. Consequently, we conducted an integrative study to identify a no-transcriptomic effect dose using...

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Identifiers

PMID: 21525395
DOI: 10.1093/toxsci/kfr099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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