Article

Podoplanin interaction with caveolin-1 promotes tumour cell migration and invasion

2018-12-06

Abstract excerpt

Podoplanin, a highly O-glycosylated type-1 transmembrane glycoprotein, found in lymphatic endothelial cells, podocytes, alveolar epithelial cells and lymph node fibroblasts is also expressed by tumour cells, and is correlated with more aggressive disease. Despite numerous studies documenting podoplanin expression, the mechanisms underlying its tumour-promoting functions remain unclear. Using a murine melanoma cell...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f1acf9d-81ec-547c-ad39-e08df921e100
DOI: 10.1101/488304

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Podoplanin interaction with caveolin-1 promotes tumour cell migration and invasionDOI 10.1101/488304Read

The potential role of podoplanin in tumour invasionSemantic proximity Read

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells.Semantic proximity Read

Podoplanin-mediated platelet activation promotes proliferation and invasion of colon cancer cellsSemantic proximity Read

Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeletonSemantic proximity Read

Caveolin-1 in Cell Migration and MetastasisSemantic proximity Read

Nischarin expression may have differing roles in male and female melanoma patientsSemantic proximity Read

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activitySemantic proximity Read

Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasisSemantic proximity Read

ECM deposition is driven by caveolin-1–dependent regulation of exosomal biogenesis and cargo sortingSemantic proximity Read

Cooperative function of oncogenic MAPK signaling and the loss of Pten for melanoma migration through the formation of lamellipodiaSemantic proximity Read

Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolaeSemantic proximity Read

Coronin 1C inhibits melanoma metastasis through regulation of MT1-MMP-containing extracellular vesicle secretion.Semantic proximity Read