Article
Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.
The Journal of biological chemistry - 4 Jun 2004
Williams Terence M, Lee Hyangkyu, Cheung Michelle W-C, Cohen Alex W, Razani Babak, Iyengar Puneeth, Scherer Philipp E, Pestell Richard G, Lisanti Michael P
Abstract excerpt
Tumorigenesis is a multistep process that involves a series of genetic changes or "multiple hits," leading to alterations in signaling, proliferation, immortalization, and transformation. Many of the molecular factors that govern tumor initiation and progression remain unknown. Here, we evaluate...
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