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Article

DNA vaccination against mutant huntingtin ameliorates the HDR6/2 diabetic phenotype.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2003

Miller Todd W, Shirley Thomas L, Wolfgang William J, Kang Xiaowei, Messer Anne

Abstract excerpt

Immunization against extracellular neurotoxic proteins has shown promise in the treatment of several neurodegenerative disorders. We sought to determine whether immunization against mutant huntingtin, the intracellular protein that causes Huntington's disease (HD), could slow disease progression in the HD mouse model HDR6/2. DNA vaccination was used to present the mutant intracellular antigen to the immune system...

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Identifiers

PMID: 12718899
DOI: 10.1016/s1525-0016(03)00063-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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