Article

Aromatic residues in mobile regions distal to the active site support the closed conformation of <i>E. coli</i> DXPS

2025-10-25

Abstract excerpt

The essential bacterial enzyme 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) is absent in humans, making the enzyme an attractive antimicrobial target. Its product DXP sits at a metabolic branchpoint between the biosynthesis of pyridoxal phosphate (PLP), thiamin diphosphate (ThDP), and isoprenoids. DXP is formed via decarboxylation of pyruvate and subsequent carboligation with D-glyceraldehyde-3-phosphate (D-GAP)...

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Literature Corpus work: 6f5293ea-01c0-5954-a365-3f5b45a59448
DOI: 10.1101/2025.10.24.684457

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Aromatic residues in mobile regions distal to the active site support the closed conformation of <i>E. coli</i> DXPSDOI 10.1101/2025.10.24.684457Read

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