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Article

Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I.

Nature communications - 12 Jan 2015

Venditti Vincenzo, Tugarinov Vitali, Schwieters Charles D, Grishaev Alexander, Clore G Marius

Abstract excerpt

Enzyme I (EI), the first component of the bacterial phosphotransfer signal transduction system, undergoes one of the largest substrate-induced interdomain rearrangements documented to date. Here we characterize the perturbations generated by two small molecules, the natural substrate phosphoenolpyruvate and the inhibitor α-ketoglutarate, on the structure and dynamics of EI using NMR, small-angle X-ray scattering...

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Identifiers

PMID: 25581904
DOI: 10.1038/ncomms6960
PMCID: PMC4293084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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