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Article

Genomic analysis of primary plasma cell leukemia reveals complex structural alterations and high-risk mutational patterns.

Blood cancer journal - 19 Jun 2020

Schinke Carolina, Boyle Eileen M, Ashby Cody, Wang Yan, Lyzogubov Valeriy, Wardell Christopher, Qu Pingping, Hoering Antje, Deshpande Shayu, Ryan Katie, Thanendrarajan Sharmilan, Mohan Meera, Yarlagadda Naveen, Khan Maliha, Choudhury Samrat Roy, Zangari Maurizio, van Rhee Frits, Davies Faith, Barlogie Bart, Morgan Gareth, Walker Brian A

Abstract excerpt

Primary plasma cell leukemia (pPCL) is a rare and aggressive form of multiple myeloma (MM) that is characterized by the presence of ≥20% circulating plasma cells. Overall survival remains poor despite advances of anti-MM therapy. The disease biology as well as molecular mechanisms that distinguish pPCL from non-pPCL MM remain poorly understood and, given the rarity of the disease, are challenging to study. In an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32555163
DOI: 10.1038/s41408-020-0336-z
PMCID: PMC7303180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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