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Article

Systems Genetics Reveals the Functional Context of PCOS Loci and Identifies Genetic and Molecular Mechanisms of Disease Heterogeneity.

PLoS genetics - 1 Aug 2015

Jones Michelle R, Brower Meredith A, Xu Ning, Cui Jinrui, Mengesha Emebet, Chen Yii-Der I, Taylor Kent D, Azziz Ricardo, Goodarzi Mark O

Abstract excerpt

Genome wide association studies (GWAS) have revealed 11 independent risk loci for polycystic ovary syndrome (PCOS), a common disorder in young women characterized by androgen excess and oligomenorrhea. To put these risk loci and the single nucleotide polymorphisms (SNPs) therein into functional context, we measured DNA methylation and gene expression in subcutaneous adipose tissue biopsies to identify...

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Identifiers

PMID: 26305227
DOI: 10.1371/journal.pgen.1005455
PMCID: PMC4549292

Genes

LHCGR
INSR
STON1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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