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Article

Polycystic Ovary Syndrome Susceptibility Loci Inform Disease Etiological Heterogeneity

18 Jun 2021

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a complex disorder with heterogenous phenotypes and unclear etiology. A recent phenotypic clustering study identified metabolic and reproductive subtypes of PCOS. We hypothesize that the heterogeneity of PCOS manifestations reflects different mechanistic pathways and can be identified using a genetic approach. We applied k-means clustering to categorize the genome-wide...

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PMID: 34207127
DOI: 10.3390/jcm10122688

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