Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).

The Journal of biological chemistry - 2 Oct 2015

Lu Sizhao, Mott Justin L, Harrison-Findik Duygu Dee

Abstract excerpt

Iron is implicated in fatty liver disease pathogenesis. The human hepcidin gene, HAMP, is the master switch of iron metabolism. The aim of this study is to investigate the regulation of HAMP expression by fatty acids in HepG2 cells. For these studies, both saturated fatty acids (palmitic acid (PA) and stearic acid (SA)) and unsaturated fatty acid (oleic acid (OA)) were used. PA and, to a lesser extent, SA, but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Fatty Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Liver

Share to Hep G2 Cells

Share to Hepcidins

Share to Palmitic Acid

Share to RNA Processing, Post-Transcriptional

Source

Open in PubMed Open full text

Identifiers

PMID: 26304124
DOI: 10.1074/jbc.M115.648212
PMCID: PMC4591806

Genes

HAMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).PMID 26304124Read ↗

RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expressionSemantic proximity Read ↗

Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuRSemantic proximity Read ↗

Hepatic HuR protects against the pathogenesis of non-alcoholic fatty liver diseaseSemantic proximity Read ↗

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cellsSemantic proximity Read ↗

Hepcidin, a key regulator of iron metabolism, is transcriptionally activated by p53.Semantic proximity Read ↗

Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation.Semantic proximity Read ↗

HuR binds to flanking exons and regulates intron retention alternative splicing of cell cycle-related genes in smooth muscle cellsSemantic proximity Read ↗

A long non-coding RNA,<i>APOA4</i>-AS, regulates<i>APOA4</i>expression depending on HuR in miceSemantic proximity Read ↗

Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2.Semantic proximity Read ↗

Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.Semantic proximity Read ↗

HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype.Semantic proximity Read ↗

The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.