Article
Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation.
Nucleic acids research - 1 Jun 2009
Al-Ahmadi Wijdan, Al-Ghamdi Maha, Al-Haj Latifa, Al-Saif Maher, Khabar Khalid S A
Abstract excerpt
The RNA-binding protein, HuR, is involved in the stabilization of AU-rich element-containing mRNAs with products that are involved in cell-cycle progression, cell differentiation and inflammation. We show that there are multiple polyadenylation variants of HuR mRNA that differ in their abundance, using both bioinformatics and experimental approaches. A polyadenylation variant with distal poly(A) signal is a rare...
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