Article
Regulatory T cells, inherited variation, and clinical outcome in epithelial ovarian cancer.
Cancer immunology, immunotherapy : CII - 1 Dec 2015
Knutson Keith L, Maurer Matthew J, Preston Claudia C, Moysich Kirsten B, Goergen Krista, Hawthorne Kieran M, Cunningham Julie M, Odunsi Kunle, Hartmann Lynn C, Kalli Kimberly R, Oberg Ann L, Goode Ellen L
Abstract excerpt
The immune system constitutes one of the host factors modifying outcomes in ovarian cancer. Regulatory T cells (Tregs) are believed to be a major factor in preventing the immune response from destroying ovarian cancers. Understanding mechanisms that regulate Tregs in the tumor microenvironment could lead to the identification of novel targets aimed at reducing their influence. In this study, we used...
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