Article
Inherited variants in regulatory T cell genes and outcome of ovarian cancer.
PloS one - 1 Jan 2013
Goode Ellen L, DeRycke Melissa, Kalli Kimberly R, Oberg Ann L, Cunningham Julie M, Maurer Matthew J, Fridley Brooke L, Armasu Sebastian M, Serie Daniel J, Ramar Priya, Goergen Krista, Vierkant Robert A, Rider David N, Sicotte Hugues, Wang Chen, Winterhoff Boris, Phelan Catherine M, Schildkraut Joellen M, Weber Rachel P, Iversen Ed, Berchuck Andrew, Sutphen Rebecca, Birrer Michael J, Hampras Shalaka, Preus Leah, Gayther Simon A, Ramus Susan J, Wentzensen Nicolas, Yang Hannah P, Garcia-Closas Montserrat, Song Honglin, Tyrer Jonathan, Pharoah Paul P D, Konecny Gottfried, Sellers Thomas A, Ness Roberta B, Sucheston Lara E, Odunsi Kunle, Hartmann Lynn C, Moysich Kirsten B, Knutson Keith L
Abstract excerpt
Although ovarian cancer is the most lethal of gynecologic malignancies, wide variation in outcome following conventional therapy continues to exist. The presence of tumor-infiltrating regulatory T cells (Tregs) has a role in outcome of this disease, and a growing body of data supports the existence of inherited prognostic factors. However, the role of inherited variants in genes encoding Treg-related immune...
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