Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative pharmacodynamics and antimutant potentials of doripenem and imipenem with ciprofloxacin-resistant Pseudomonas aeruginosa in an in vitro model.

Antimicrobial agents and chemotherapy - 1 Mar 2012

Firsov Alexander A, Gilbert Deborah, Greer Kenneth, Portnoy Yury A, Zinner Stephen H

Abstract excerpt

To compare the antipseudomonal efficacy of doripenem and imipenem as well as their abilities to restrict the enrichment of resistant Pseudomonas aeruginosa, multiple-dosing regimens of each drug were simulated at comparable values of the cumulative percentages of a 24-h period that the drug concentration exceeds the MIC under steady-state pharmacokinetic conditions (T(>MIC)) and ratios of the 24-hour area under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Area Under Curve
Share to Carbapenems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ciprofloxacin

Share to Drug Resistance, Bacterial

Share to Imipenem

Share to Predictive Value of Tests

Share to Pseudomonas aeruginosa

Share to Pseudomonas Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 22203591
DOI: 10.1128/AAC.05964-11
PMCID: PMC3294888

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative pharmacodynamics and antimutant potentials of doripenem and imipenem with ciprofloxacin-resistant Pseudomonas aeruginosa in an in vitro model.PMID 22203591Read ↗

Concentration-resistance relationships with Pseudomonas aeruginosa exposed to doripenem and ciprofloxacin in an in vitro model.Semantic proximity Read ↗

Suppression of ciprofloxacin-induced resistant Pseudomonas aeruginosa in a dynamic kill curve system.Semantic proximity Read ↗

Mechanisms responsible for imipenem resistance among Pseudomonas aeruginosa clinical isolates exposed to imipenem concentrations within the mutant selection window.Semantic proximity Read ↗

Impact of different carbapenems and regimens of administration on resistance emergence for three isogenic Pseudomonas aeruginosa strains with differing mechanisms of resistance.Semantic proximity Read ↗

Bacterial antibiotic resistance studies using in vitro dynamic models: Population analysis vs. susceptibility testing as endpoints of mutant enrichment.Semantic proximity Read ↗

Pharmacokinetic/pharmacodynamic model-based combination therapy approach to target antibiotic resistant populations emerged from ciprofloxacin exposure.Semantic proximity Read ↗

Development of resistance in wild-type and hypermutable Pseudomonas aeruginosa strains exposed to clinical pharmacokinetic profiles of meropenem and ceftazidime simulated in vitro.Semantic proximity Read ↗

Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential.Semantic proximity Read ↗

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapy.Semantic proximity Read ↗

Application of a mathematical model to prevent in vivo amplification of antibiotic-resistant bacterial populations during therapySemantic proximity Read ↗

Dynamic interaction of colistin and meropenem on a WT and a resistant strain ofPseudomonas aeruginosaas quantified in a PK/PD modelSemantic proximity Read ↗

Bacterial‐Population Responses to Drug‐Selective Pressure: Examination of Garenoxacin's Effect onPseudomonas aeruginosaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.