Article
Enrichment of fluoroquinolone-resistant Staphylococcus aureus: oscillating ciprofloxacin concentrations simulated at the upper and lower portions of the mutant selection window.
Antimicrobial agents and chemotherapy - 1 Jun 2008
Firsov Alexander A, Lubenko Irene Y, Smirnova Maria V, Strukova Elena N, Zinner Stephen H
Abstract excerpt
The time inside the mutant selection window (MSW), T(MSW), appears to be less predictive of the selection of fluoroquinolone-resistant Staphylococcus aureus than is the ratio of the area under the concentration-time curve (AUC) to the MIC. This observation might be attributed to the fact that T(MSW) does not consider the actual position of simulated antibiotic concentrations inside the MSW, which also might...
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