Article
Genetics of Frontotemporal Dementia.
Current neurology and neuroscience reports - 1 Dec 2016
Olszewska Diana A, Lonergan Roisin, Fallon Emer M, Lynch Tim
Abstract excerpt
Frontotemporal dementia (FTD) is the second most common cause of dementia following Alzheimer's disease (AD). Between 20 and 50% of cases are familial. Mutations in MAPT, GRN and C9orf72 are found in 60% of familial FTD cases. C9orf72 mutations are the most common and account for 25%. Rarer mutations (<5%) occur in other genes such as VPC, CHMP2B, TARDP, FUS, ITM2B, TBK1 and TBP. The diagnosis is often...
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