Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.

The Journal of biological chemistry - 21 May 1999

Grover A, Houlden H, Baker M, Adamson J, Lewis J, Prihar G, Pickering-Brown S, Duff K, Hutton M

Abstract excerpt

Missense and splice site mutations in the microtubule-associated protein tau gene were recently found associated with fronto-temporal dementia and parkinsonism linked to chromosome 17 (Poorkaj et al. (1998) Ann. Neurol. 43, 815-825; Hutton et al. (1998) Nature 393, 702-705; Spillantini et al. (19...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Dementia
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Microtubule-Associated Proteins

Share to Protein Structure, Secondary

Share to RNA, Messenger

Share to tau Proteins

Source

Identifiers

PMID: 10329720
DOI: 10.1074/jbc.274.21.15134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10329720-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.PMID 10329720Read ↗

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10Semantic proximity Read ↗

Tau exon 10 alternative splicing and tauopathiesSemantic proximity Read ↗

A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17.Semantic proximity Read ↗

Alternative splicing of exon 10 in the tau gene as a target for treatment of tauopathies.Semantic proximity Read ↗

The Tau N279K Exon 10 Splicing Mutation Recapitulates Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Tauopathy in a Mouse ModelSemantic proximity Read ↗

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors.Semantic proximity Read ↗

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.Semantic proximity Read ↗

Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17.Semantic proximity Read ↗

Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17.Semantic proximity Read ↗

Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.Semantic proximity Read ↗

A novel mutation at position +12 in the intron following Exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)Semantic proximity Read ↗

A new family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.