Article
Association of genetic polymorphisms in CD8+ T cell inhibitory genes and susceptibility to and progression of chronic HBV infection.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2015
Peng Hong, Li Qing-Ling, Hou Si-Hui, Hu Jun, Fan Jia-Hao, Guo Jin-Jun
Abstract excerpt
BACKGROUND: Previous studies have shown that multiple inhibitory genes play an important role in HBV-specific CD8+ T cell exhaustion and dysfunction in the setting of chronic HBV infection. Polymorphic variants of these genes are thought to be predisposing factors for HBV susceptibility, clearanc...
Topics
- Adult
- Aged
- Alleles
- Antigens, CD
- Apoptosis Regulatory Proteins
- Bcl-2-Like Protein 11
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- Disease Progression
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype